胸腺上皮细胞

胸腺上皮细胞(查了两篇文章，下面是其中一篇Thymic microenvironments for T-cell repertoire formation的abstract部分，全文没有查到。我做了一

胸腺上皮细胞 ( Thymic microenvironments for T-cell repertoire formation 查了两篇文章，下面是其中一篇 abstract 的部分，全文没有查到。我做了一下搬运工工作，可能翻译的不太准确，所以把 ) 原文也贴了一下。 The recent discovery of thymoproteasomes, amolecular complex specifically expressed in cortical thymic epithelial cells (cTEC), has revealed aunique role of cTEC in cuing the further development of immature thymocytes in thymic cortex, possibly by displaying unique self-peptides that induce positive selection. Cortical thymocytes that receive TCR-mediated positive selection signals are destined to survive for further differentiation and are induced to express CCR7, achemokine receptor. Being attracted to CCR7 ligands expressed by medullary thymic epithelial cells (mTEC), CCR7-expressing positively selected thymocytes relocate to thymic medulla. The medullary microenvironment displays another set of unique self-peptides for trimming positively selected T-cellrepertoire to establish self-tolerance, via promiscuous expression of tissue-specific antigens by mTEC and efficient antigen presentation by dendritic cells. Recent results demonstrate that tumor necrosis factor (TNF) superfamily ligands, including receptor activating NF-kappaB ligand (RANKL), CD40L, and lymphotoxin, are produced by positively selected thymocytes and pivotally regulate mTEC development and thymic medulla formation . cTECthymoproteasomecTEC 在中特异表达的表明对胸腺皮质中未成熟胸腺 细胞的进一步发育有重要作用，这一作用是通过表达独特的自身肽引起阳性选择 TCR 实现的。经过介导的阳性选择的皮质胸腺细胞可以进入分化阶段并且被诱 CCR7CCR7mTECCCRL7 导表达。这些表达了的胸腺细胞被表达的吸引重 mTECTSA 新定位于胸腺髓质。髓质微环境亦表达一类自身肽，通过随机表达 DCT 和有效的抗原呈递，使阳性选择的细胞形成自身耐受。