新生期大鼠母爱剥夺对成年后自发活动的影响

新生期大鼠母爱剥夺对成年后自发活动的影响【摘要】 目的:观察新生期母爱剥夺对大鼠成年后自发活动的影响。方法:将母鼠随机分为母爱剥夺(MD)组(所生仔鼠在出生后第2，21d每天母婴分离1h)和正常对照(

新生期大鼠母爱剥夺对成年后自发活动的影响 【摘要】 目的:观察新生期母爱剥夺对大鼠成年后自发 活动的影响。方法:将母鼠随机分为母爱剥夺(MD)组(所生仔鼠在出 生后第2，21d每天母婴分离1h)和正常对照(N)组(所生仔鼠不做任 何处理)。仔鼠成年后予慢性应激～用开场试验观察大鼠自发活动的 改变。结果:MD组再次受到慢性应激后可引起自发活动总路程与周 边路程的显著减少(P<0.001)～休息时间增加(P<0.01)。结论: 新生期大鼠母爱剥夺可引起成年后自发活动减少～导致抑郁样行为。 【关键词】 母爱剥夺 抑郁样行为 自发活动 ,Abstract,Objective:To investigate the effect of neonatal maternal separation on the locomotion activity in adult rats. Methods:The neonatal SD rats were randomly divided into maternal separation group(one hour daily maternal separation on postnatal day 2， 21)and control group(no handing on postnatal day 2，21). The rat received chronic stresses in adult period. The autonomic behavior was determined by animal behavior analysis system. Results:In the maternal separation group after chronic stress,the total distance and the surrounding distance of rats gradually decreased(P<0.001), and the rest time increased(P<0.01). The neonatal maternal separation can decrease locomotion activity in rats, it can cause behavior depression in posse. ,Key Words,neonatal maternal separation; behavior depression;