普萘洛尔对雌性小鼠主动脉MMP-9,VEGF,bFGF表达的影响的实验研究

普萘洛尔对雌性小鼠主动脉MMP-9,VEGF,bFGF表达的影响的实验研究Abstract: This study aimed to investigate the effects of Propra

MMP-9,VEGF,bFGF 普萘洛尔对雌性小鼠主动脉表 达的影响的实验研究 Abstract: This study aimed to investigate the effects of Propranolol on the expression of MMP-9,VEGF,bFGF in the aorta of female mice. We used atotal of 30 female mice, which were divided into three groups, with each group receiving adifferent treatment for 14 days: group A received normal saline, group Breceived low-dose Propranolol (10mg/kg), and group Creceived high-dose Propranolol (20mg/kg). After treatment, the aorta tissue of the mice was collected, and the expression of MMP-9, VEGF, and bFGF was detected by immunohistochemistry and Western blotting methods. Our results showed that the expression of MMP-9, VEGF, and bFGF in the aorta of female mice was significantly downregulated after treatment with both low-dose and high-dose Propranolol, with high-dose treatment showing amore pronounced effect. These findings suggest that Propranolol may have apotential protective effect on the development of cardiovascular diseases in women by suppressing the expression of MMP-9, VEGF, and bFGF in the aorta. Introduction: Cardiovascular disease (CVD) is amajor cause of mortality worldwide, with increasing prevalence among women. The pathogenesis of CVD is complex and multifactorial, with various mechanisms involved, including inflammatory response, oxidative stress, and angiogenesis. Among these mechanisms, angiogenesis plays akey role in the occurrence and development of CVD. The formation of new blood vessels is an important process in the development of collateral circulation in vascular diseases, including atherosclerosis, hypertension, and aneurysms. Angiogenesis is regulated by various signaling molecules, including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), which promote the formation of new blood vessels by stimulating the proliferation, migration, and differentiation of vascular endothelial cells. Matrix metalloproteinase-9 (MMP-9) is an important member of the MMP family, which plays acrucial role in the degradation of extracellular matrix (ECM) components and the remodeling of blood vessels. MMP-9 is involved in the pathogenesis of CVD by promoting the migration and proliferation of smooth muscle cells, reducing the stability