HPLC法测定吗氯贝胺片的含量

HPLC法测定吗氯贝胺片的含量?373? effectsonthedissociationofthecarhoxylgroup.Anal Chem,1988,60(17):1673 <本文于19

HPLC法测定吗氯贝胺片的含量 ?373? effectsonthedissociationofthecarhoxylgroup.Anal Chem,1988,60(17):1673 &amp;lt;本文于1996年l1月4日收到) DeterminationofFourQuinolonesby HighPerformanceCapillaryElectrophoresis YinChaandWuYutian (DepartmeatofPha~aceuticalA曲 m,TheSecondMilitary~edicalUniv~rslty,Shanghai,200433) Abstract:Asimpleandrapidmethodwasdevelopedforthesimultaneousdetermin ationof fourquinolones(1omefloxacinhydrochloride,enoxacin,ciprofloxacinhydrochlo rideand ofloxacin)bycapillaryzoneelectr0phoresis(CZE).Abuffersolutionthatcontain ed50mtool/ Lsodiumborateandsodiumdihydrogenphosphate(pH8.5)wasfoundtobethemosts uitable electrolyte[orthisseperation.Theappliedvoltagewas18kVandUVdetectionwavel engthwas 214nm.Carfeinew丑 susedasinternalstandard.Thelinearrangesofthecalibrationcurveswere 20~t20mg/L(r&amp;gt;0-9995)anddetectionlimitswereO.4,O.48mg/L(S/N一3j1).