壳聚糖—左氧氟沙星长效缓释微球的制备及性能研究

壳聚糖—左氧氟沙星长效缓释微球的制备及性能研究摘要壳聚糖—左氧氟沙星长效缓释微球的制备及性能研究，旨在研究一种新型嵌段聚合物材料壳聚糖与一种广谱、有效、可用于医疗领域的抗生素左氧氟沙星制备的缓释微球。

— 壳聚糖左氧氟沙星长效缓释微球的制备及性能研究 摘要 壳聚糖—左氧氟沙星长效缓释微球的制备及性能研究，旨在研究一 种新型嵌段聚合物材料壳聚糖与一种广谱、有效、可用于医疗领域的抗 生素左氧氟沙星制备的缓释微球。采用离子凝胶法将壳聚糖与左氧氟沙 星复配，并应用乳化剂—稳定剂法制备长效缓释微球。通过扫描电镜观 察微球表面形貌、热重分析微球的稳定性、红外光谱研究微球中材料的 结构等方法，探究了壳聚糖—左氧氟沙星长效缓释微球的制备工艺及性 能。研究结果表明，在制备工艺中控制好各项条件，壳聚糖—左氧氟沙 星长效缓释微球的效果显著，可以作为新型药物制剂的研究方向之一。 关键词：壳聚糖，左氧氟沙星，长效缓释微球，制备，性能研究 Abstract Thepreparationandperformanceresearchof chitosan-levofloxacinsustained-releasemicrospheresisaimedat studyinganovelblockcopolymermaterialchitosananda broad-spectrum,effective,andmedical-useantibioticlevofloxacin topreparesustained-releasemicrospheres.Thechitosanand levofloxacinarecombinedbyiongelationmethod,and long-actingsustained-releasemicrospheresarepreparedbyusing emulsifier-stabilizermethod.Scanningelectronmicroscopywas usedtoobservethesurfacemorphologyofthemicrospheres, thermogravimetricanalysiswasusedtostudythestabilityofthe microspheres,andinfraredspectroscopywasusedtostudythe structureofthematerialsinthemicrospheres.Thepreparation processandperformanceofchitosan-levofloxacin sustained-releasemicrosphereswerestudied.Theresultsshow thattheeffectofchitosan-levofloxacinlong-acting sustained-releasemicrospheresissignificantwhenvarious conditionsarecontrolledwellinthepreparationprocess.Itcanbe usedasoneoftheresearchdirectionsofnoveldrugformulations. Keywords:chitosan,levofloxacin,sustained-release microspheres,preparation,performanceresearch 正文