DNA纳米结构自装配的语言能力分析(英文)

DNA纳米结构自装配的语言能力分析(英文)In recent years, the field of DNA nanotechnology has gained significant attenti

DNA() 纳米结构自装配的语言能力分析英文 Inrecentyears,thefieldofDNAnanotechnologyhasgained significantattentionduetotheremarkableabilityofDNA moleculestoself-assembleintocomplex3Dstructures.Thisability ofDNAmoleculestoself-assembleintocomplexstructuresisdue totheiruniquesequence-dependentbasepairinginteractions. Theuseoftheseinteractionshasallowedresearcherstocreatea newtoolboxfordesigningandcreatingfunctionalnanoscale devicesfordrugdelivery,sensing,andotherapplications. OneofthemajoradvantagesofusingDNAasabuilding materialfornanotechnologyisitshighspecificityofbase-pairing interactions.ThebasepairingrulesofDNA,whereAonlybinds withTandConlybindswithG,allowforahighdegreeof specificityinthedesignofDNAnanotechnology.Thesebase pairinginteractionshaveallowedresearcherstodesignand constructcomplex3Dstructureswithhighprecisionandaccuracy. TheprocessofDNAself-assemblyisdrivenbythe complementarybasepairingbetweentheDNAsequences.This processisanalogoustotheformationofajigsawpuzzlewhere theindividualpiecesfittogetherbasedontheirrespectiveshapes. ThedifferencewithDNAself-assemblyisthattheindividualpieces areDNAstrandsthataredesignedtoformspecificinteractions withotherDNAstrandsinthesystem.Thefinalstructurecanbe controlledthroughtheselectionoftheDNAsequencesandthe solutionconditionssuchastemperatureandsaltconcentration. ThelanguageofDNAsequenceshasallowedresearchersto designawiderangeofstructuresfromsimplelineararraysto complex3Dstructures.Oneofthepioneeringworksinthisfield wasthecreationofDNAorigami,wherealongsingle-stranded DNAmoleculeisfoldedintoaspecificshapeusingseveralshort DNAoligonucleotidesasstaples.Thedesignofthesestaplesis criticaltothefinalstructure,andtheindividualsequencesmustbe carefullyselectedtoensurethecorrectfoldingofthemolecule. ThisprocesshasdemonstratedtheabilityofDNAtoactas scaffoldsforbuildingmorecomplexstructureswithhigh precision. ApartfromDNAorigami,DNAtileshavealsobeenused extensivelyforcreatingcomplexstructures.Inthismethod,small