N,N‘-二甲苯基二硫代草酰胺合成方法的改进

N,N‘-二甲苯基二硫代草酰胺合成方法的改进Title: Improvements in the Synthetic Methods of N,N'-dimethylthioureaAbstract:

N,N‘- 二甲苯基二硫代草酰胺合成方法的改进 Title:ImprovementsintheSyntheticMethodsof N,N'-dimethylthiourea Abstract: N,N'-dimethylthioureaisaversatilecompoundthatfinds applicationinvariousindustries,suchasagriculture, pharmaceuticals,andmaterialsscience.Thispaperaimstoexplore andanalyzetheexistingsyntheticmethodsof N,N'-dimethylthioureaandproposepotentialimprovementsto enhancetheefficiency,yield,andpurityofthecompound synthesis. Introduction: N,N'-dimethylthiourea(DMTU)isasulfur-containing compoundwiththechemicalformula(CH3)2NCS(NH2)CH3.Itisa whitecrystallinesolidthatissolubleinpolarsolvents.DMTUhas beenextensivelyusedasachelatingagent,vulcanization accelerator,corrosioninhibitor,andintermediateinthesynthesis ofpharmaceuticals,dyes,andpesticides.Thecurrentmethodsof synthesizingDMTUinvolvethereactionofN,N-dimethylureawith elementalsulfurorcarbondisulfide(CS2),followedbythe additionofasulfuratingagent.However,thesemethodssuffer fromlowyields,sidereactions,andpoorselectivity,which necessitatesimprovements. SyntheticMethods: 1.N,N-dimethylureareactswithelementalsulfur: ThereactionbetweenN,N-dimethylureaandelementalsulfur isoneofthemostcommonmethodsforsynthesizingDMTU. However,thismethodoftenresultsinlowyieldsduetoundesired sidereactions,suchastheformationofthiazolederivatives.One possibleimprovementistouseacatalyst,suchasaLewisacidora base,toincreasethereactionrateandselectivity. 2.N,N-dimethylureareactswithcarbondisulfide: Analternativemethodinvolvesthereactionbetween N,N-dimethylureaandcarbondisulfide(CS2),followedbythe additionofasulfuratingagenttoproduceDMTU.Thismethod hasadvantagesovertheelementalsulfurmethod,asitisa