乳腺癌组织中p53nm23-H1基因表达及其与绝经状态淋巴结转移的相关性医学论文

乳腺癌组织中p53、nm23-H1基因表达及其与绝经状态、淋巴结转移的相关性_医学论文 【摘要】 　　［目的］ 研究乳腺癌患者中p53和nm23-H1基因表达，及其与绝经状态及腋窝淋巴结转移的关系。［

乳腺癌组织中p53、nm23-H1基因表达及其与绝经状态、淋巴结转移的相关性_ 医学论文 【摘要】 ［目的］ 研究乳腺癌患者中p53和nm23-H1基因表达，及其与 绝经状态及腋窝淋巴结转移的关系。［方法］ 采用免疫组织化学SP方法检测 60例乳腺癌组织中p53和nm23-H1的表达。［结果］ 60例乳腺癌患者中，p53 和nm23-H1的阳性表达率分别为73.3%(44/60)和66.7%(40/60); 在绝经前患者 中p53和nm23-H1的阳性表达率分别为66.7%（16/24）和50.0%（12/24），而 在绝经后患者中两者的阳性表达率分别为77.8%（28/36）和77.8%（28/36）。 在绝经后患者中p53和nm23-H1基因的阳性表达与腋窝淋巴转移呈显著性相关 （P=0.019和P=0.019）。［结论］ p53可能参与绝经前妇女乳腺癌的发生， 可能促进绝经后乳腺癌的转移；而nm23-H1可能参与绝经后乳腺癌的转移。 【关键词】 乳腺肿瘤 p53 nm23-H1 淋巴结 绝经 Expression of p53 and nm23-H1 in the Tissues of Breast Cancer and Its Correlation with Menopausal Status and Lymphatic Metastasis Abstract: ［Purpose］ To study the role of expression of p53 and nm23-H1 in lymphatic metastasis of breast cancer, and the correlation between expression of p53 and nm23-H1. ［Methods］ Expression of p53 and nm23-H1 in 60 patients with breast cancer was detected by immunohistochemical S-P method. ［Results］ Of 60 cases with breast cancer, 44 cases (73.3%) and 40 cases (66.7%) were positive for p53 and nm23-H1 protein respectively. In premenopausal patients with breast cancer, expression of p53 and nm23-H1 was 66.7% and 50.0% respectively, and in postmenopausal that was 77.8% and 77.8% respectively. In postmenopausal patients with breast cancer, expression of p53 and nm23-H1 was related to lymphatic metastasis （P=0.019 and P=0.019）. ［Conclusion］ p53 may play an role in the carcinogenesis of breast cancer in premenopausal patients by the regulation of endocrine system, and could promote lymphatic metastasis in postmenopausal breast cancer patients. nm23-H1 gene may take part in lymphatic metastasis in postmenopausal breast cancer patients. Key words: breast neoplasms; p53; nm23-H1; lymphnode; menopause 乳腺癌是妇女中最常见的恶性肿瘤，抑癌基因p53和转移抑制基因nm23?鄄H1 都与乳腺癌的发生 发展 有关[1，2]。本研究采用免疫组织化学方法检测60例 乳腺癌组织中p53和nm23?鄄H1的表达，探讨其与乳腺癌临床病理参数之间的 关系。 1材料与方法 1.1 材料