N-硝基-N-取代苯基酰胺的合成、生物活性及3D-QSAR研究

N-硝基-N-取代苯基酰胺的合成、生物活性及3D-QSAR研究Title: Synthesis, Biological Activity, and 3D-QSAR Study of N-Nitro-N

N--N- 硝基取代苯基酰胺的合成、生物活性及 3D-QSAR 研究 Title:Synthesis,BiologicalActivity,and3D-QSARStudyof N-Nitro-N-substitutedBenzamide Abstract: N-Nitro-N-substitutedbenzamidesareaclassoforganic compoundswithdiverseapplicationsinthepharmaceuticaland agriculturalindustries.Thispaperaimstoexplorethesynthetic methods,biologicalactivities,andthree-dimensionalquantitative structure-activityrelationship(3D-QSAR)studiesof N-nitro-N-substitutedbenzamides. Introduction: N-Nitro-N-substitutedbenzamidesarederivativesof benzamideinwhichthenitrogenoftheamidegroupis substitutedbyanitrogroup(NO2)andthearomaticringisfurther substituted.Thesecompoundsexhibitarangeofpharmacological andbioactiveproperties,includinganalgesic,anti-inflammatory, antimicrobial,andantitumoractivities.Thesynthesisof N-nitro-N-substitutedbenzamidesinvolvesseveralmethods, includingnitrationandN-substitutionreactions.Thebiological activityofthesecompoundshasattractedsignificantattention,as theyhaveshownpromisingresultsinvariousdrugdiscovery programs. Synthesis: ThesynthesisofN-nitro-N-substitutedbenzamidestypically involvesatwo-stepreaction:nitrationofbenzamidefollowedby N-substitution.Thenitrationprocesscanbecarriedoutusinga varietyofreagents,suchasconcentratednitricacid,nitrousacid, ormetalnitrates.TheN-substitutionreactioncanbeachievedby treatingthenitrobenzamidewithappropriateN-substituting agentsorcatalysts.Differentsyntheticapproacheshavebeen employedtoobtainvariousN-nitro-N-substitutedbenzamides, allowingfortheintroductionofdifferentsubstituentsonthe aromaticring. BiologicalActivities: